In vitro cytotoxicity of Auger electron-emitting [67Ga]Ga-trastuzumab

Dosimetry of Auger-Electron-Emitting Radionuclides

Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I

UNLABELLED BACKGROUND This study evaluates the potential utility of a modular nanotransporter (MNT) for enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125I in cancer cells that overexpress the epidermal growth factor receptor (EGFR). METHODS MNTs are recombinant multifunctional polypeptides that we have developed for achieving selective delivery of short-rang...

Monte Carlo evaluation of Auger electron-emitting theragnostic radionuclides

Monte Carlo Evaluation of Auger Electron-Emitting Theranostic Radionuclides.

UNLABELLED Several radionuclides used in medical imaging emit Auger electrons, which, depending on the targeting strategy, either may be exploited for therapeutic purposes or may contribute to an unintentional mean absorbed dose burden. In this study, the virtues of 12 Auger electron-emitting radionuclides were evaluated in terms of cellular S values in concentric and eccentric cell-nucleus arr...

Evaluation of DNA damage in a Her2+ cell line induced by an Auger-emitting immunoconjugate

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...